Publications

Eijansantos E, Allen IE, de Leon J, Grasso, S, Rogers N, Bogley R, Paramo A, Ehrenberg AJ, Montembeault M, Sturm V, Spina S, Grinberg LT, Seeley WW, Rankin KP, Kramer JH, Rosen HJ, Rabinovici GD, Gorno-Tempini ML, Miller BL, Perry DC, Miller ZA. Burden of psychiatric disease inversely correlates with Alzheimer's age at onset. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2025. PMID: 41131662. PubMed

Zsadanyi S, Addison E, Alladi S, Andrews S, Keerthana, Carello-Collar G, Dubljević O, Ehrenberg AJ, Farina F, Grinberg L, Ibanez A, Martersteck A, Nigussie A, Rogalski E, Seibert K, Stefanova E, Yaffe K, Zewde Y, Zimmer E, Fontana F. Democratizing Dementia Research Through Global Online Conferences. Nature Neuroscience. 2025. PMID: 40325214. PubMed

Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T. A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease. Nature Medicine. 2025 Mar 31. PMID: 40164724. PubMed

Ehrenberg AJ, Sant C, Pereira FL, Li SH, Buxton J, Langlois S, Trinidad M, Oh I, Leite REP, Rodriguez RD, Paes VR, Pasqualucci CA, Seeley WW, Spina S, Suemoto CK, Temple S, Kaufer D, Grinberg LT. Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2025. PMID: 40135662. PubMed

Richardson TE, Orr ME, Orr TC, Rohde SK, Ehrenberg AJ, Thorn EL, Christie TD, Flores-Almazan V, Afzal R, De Sanctis C, Maldonado-Díaz C, Hiya S, Canbeldek L, Kulumani Mahadevan LS, Slocum C, Samanamud J, Clare K, Scibetta N, Yokoda RT, Koenigsberg D, Marx GA, Kauffman J, Goldstein A, Selmanovic E, Drummond E, Wisniewski T, White CL 3rd, Goate AM, Crary JF, Farrell K, Alosco ML, Mez J, McKee AC, Stein TD, Bieniek KF, Kautz TF, Daoud EV, Walker JM. Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2025. PMID: 39737785. PubMed

Gontrum EQ, Paolillo EW, Lee S, Diaz V, Ehrenberg AJ, Saloner R, Mundada NS, La Joie R, Rabinovici G, Kramer JH, Casaletto K. Neuropsychiatric profiles and cerebral amyloid burden in adults without dementia. Dementia and Geriatric Cognitive Disorders. 2024. PMID: 38513620. PubMed

Karvelas N, Oh B, Wang E, Cobigo Y, Tsuei T, Fitzsimons S, Younes K, Ehrenberg AJ, Geschwind MD, Schwartz D, Kramer JH, Ferguson AR, Miller BL, Silbert LC, Rosen HJ, Elahi FM. Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Communications. 2024. PMID: 38495305. PubMed

Walker JM, Orr ME, Orr TC, Thorn E, Christie T, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond ES, White CL, Crary JF, Farrell K, Kautz TF, Daoud EV, Richardson TE. Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer disease and primary age-related tauopathy. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2023. PMID: 37777848. PubMed

Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT. Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 19(5), 2182–2196. 2023. PMID: 36642985. PubMed

Theofilas P, Piergies AMH, Li SH, Petersen C, Ehrenberg AJ, Eser RA, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT. [Pre-print] Caspase-6-cleaved tau is relevant in Alzheimer’s disease but not in 4-repeat tauopathies: diagnostic and therapeutic implications. Neuropathology and Applied Neurobiology. e12819. 2022. PMID: 35508761. PubMed

Mattsson-Carlgren N, Grinberg LT, Boxer A, Ossenkoppele R, Jonsson M, Seeley W, Ehrenberg AJ, Spina S, Janelidze S, Rojas-Martinez J, Rosen H, La Joie R, Lesman-Segev O, Iaccarino L, Kollmorgen G, Ljubenkov P, Eichenlaub U, Gorno-Tempini ML, Miller B, Hansson O, and Rabinovici GD. Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration. Neurology. 98(11): e1137-e1150. 2022. PMID: 35173015. PubMed

Brook CE, Northrup GR, Ehrenberg AJ, the IGI Testing Consortium, Doudna JA, Boots M. Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment. Epidemics. 37: 100527. 2021. PMID: 34814094. PubMed

Stahl EC, Gopez AR, Tsuchida CA, Fan VB, Moehle EA, Witkowsky LB, Hamilton JR, Lin-Shiao E, McElroy M, McDevitt SL, Ciling A, Tsui CK, Pestal K, Gildea HK, Keller A, Sylvain IA, Williams C, Hirsh A, Ehrenberg AJ, Kantor R, Metzger M, Nelson KL, Urnov FD, Ringeisen BR, Giannikopoulos P, Doudna JA. IGI Testing Consortium. LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples. PLoS One. 16(11): e0258263. 2021. PMID: 34758033. PubMed

Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, Ehrenberg AJ, IGI SARS-CoV-2 consortium, Ringeisen BR, Huberty G, Urnov FD, Giannikopoulos P, Doudna JA. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. PLoS One. 16(8): e0255690. 2021. PMID: 34351984. PubMed

Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, Pestal K, Frankino PA, Murley A, Nandakumar D, Stahl EC, Tsuchida CA, Gildea HK, Murdock AG, Hochstrasser ML, O'Brien E, Ciling A, Tsitsiklis A, Worden K, Dugast-Darzacq C, Hays SG, Barber CC, McGarrigle R, Lam EK, Ensminger DC, Bardet L, Sherry C, Harte A, Nicolette G, Giannikopoulos P, Hockemeyer D, Petersen M, Urnov FD, Ringeisen BR, Boots M, Doudna JA; IGI SARS-CoV-2 Testing Consortium. Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus. PLoS One. 2021. PMID: 34038425. PubMed

Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller BL, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathologica. 2021. PMID: 33677647. PubMed

Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease. Nature Neuroscience. 24(2): 276-287. 2021. PMID: 33432193. PubMed

Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Resende EDPF, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SYYP, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathology. e12924. 2020. PMID: 33314436. PubMed

IGI SARS-CoV-2 Testing Consortium [including Ehrenberg AJ]. Blueprint for a pop-up SARS-CoV-2 testing lab. Nature Biotechnology. 38(7): 791-797. 2020. PMID: 32555529. PubMed

Ehrenberg AJ, Khatun A, Coomans E, Betts M, Capraro F, Thijssen E, Senkevich K, Bharucha T, Schott JM, Pereira J, Mattsson N, Grinberg LT, Jagust W, Lashley T, Carter SF, Ashton N, Hanrieder J, Zetterberg H, Schöll M, Paterson RW. Relevance of Biomarkers Across Different Neurodegenerative Diseases. Alzheimer’s Research and Therapy. 12(56). 2020. PMID: 32404143. PubMed

Ehrenberg AJ, Morales DO, Piergies AMH, Li SH, Tejedor JS, Mladinov M, Mulder J, Grinberg LT. A manual multiplex immunofluorescence method for investigating neurodegenerative diseases. Journal of Neuroscience Methods. 39: 108708. 2020. PMID: 32243897. PubMed

Resende EDPF, Nolan AL, Petersen C, Ehrenberg AJ, Miller Z, Spina S, Miller BL, Seeley WW, Rosen HJ, Grinberg LT. Language & spatial dysfunction in Alzheimer’s disease with white matter thorn shaped astrocytes. Neurology. 94(13): e1353-e1364. 2020. PMID: 32001514. PubMed

Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT. Profound degeneration of wake-promoting neurons in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 15(10): 1253–1263. 2019. PMID: 31416793. PubMed

Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT. Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathologica. 138(4): 597–612. 2019. PMID: 31250152. PubMed

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain. 142(9): 2558–2571. 2019. PMID: 31327002. PubMed

Betts M, Ehrenberg AJ, Hämmerer D, Duzel E. Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. Frontiers in Neuroscience. 12:401. 2018. PMID: 29928191. PubMed

Ehrenberg AJ, Suemoto CK, Resende EDPF, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer J, Gatchel J, Grinberg LT. Neuropathologic correlates of psychiatric symptoms in Alzheimer’s disease. Journal of Alzheimer’s Disease. 66(1): 115-126. 2018. PMID: 30223398. PubMed

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study. Journal of Neuropathology and Experimental Neurology. 77(2): 149-161. 2018. PMID: 29304218. PubMed

Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Leite REP, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiology of Aging. 61: 1-12. 2018. PMID: 29031088. PubMed

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Alho AT, Leite RP, Rodriguez RD, Mejia MB, Rüb U, Farfel JM, Ferretti-Rebustini REL, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's Disease. Neuropathology and Applied Neurobiology. 43(5): 393-408. 2017. PMID: 28117917. PubMed

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 13(3): 236-246. 2017. PMID: 27513978. PubMed