Mechanisms of neurodegeneration. Transforming care.

The Neuronal Resilience and Vulnerability in Aging (NERVA) Research Lab is led by Alexander Ehrenberg at the UCSF Fein Memory and Aging Center and the Innovative Genomics Institute. We uncover the mechanisms that underlie neuronal vulnerability and resilience in aging. By combining experimental models, human neuropathology, and genomic approaches, we map the biology of neurodegeneration across systems. We use these insights to develop precision cell and gene therapies.

Alexander Ehrenberg, PhD

Alexander Ehrenberg is the principal investigator of the Neuronal Resilience and Vulnerability in Aging (NERVA) Lab. He is a biomedical scientist focused on understanding the pathogenesis of neurological and psychiatric diseases and translating disease mechanisms into new therapeutic strategies. Dr. Ehrenberg received his BA and PhD from UC Berkeley, with additional research training at the UCSF Memory and Aging Center under the mentorship of Dr. Lea Grinberg and Dr. Daniela Kaufer. His graduate research focused on mechanisms of selective neuronal vulnerability in Alzheimer’s disease and stress disorders, with training spanning neuropathology, epidemiology, comparative neurology, molecular genetics, and cell biology. Following his PhD, he completed a Translational Health Fellowship at the Innovative Genomics Institute under the mentorship of Dr. Jennifer Doudna and Dr. Bruce Miller, where he expanded his work into functional genomics, genome editing, and therapeutic development.

Dr. Ehrenberg is now an Investigator at the Innovative Genomics Institute and an Associate Professional Researcher at the UCSF Edward and Pearl Fein Memory and Aging Center. His research program integrates human neuropathology, spatial molecular profiling, functional genomics, and genome engineering to understand why particular neuronal populations are vulnerable or resilient to age-associated disease and to identify and develop targets for cell and gene therapies.